Regulation of Ca2+/calmodulin dependent protein kinase kinase-2 by phosphorylation

通过磷酸化调节 Ca2/钙调蛋白依赖性蛋白激酶激酶 2

• 批准号: nhmrc : 1028256
• 负责人: Dr John Scott
• 金额: $ 38.03万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-ca2calmodulin-dependent-2-phosphorylation/110620
• 关键词: Regulation; Ca2+; calmodulin; dependent; protein

This project will study the regulation of an enzyme called CaMKK2, which plays a pivotal role in controlling a number of important biological functions including brain development, regulation of appetite, energy metabolism and blood pressure. Understanding how this enzyme is regulated may open new avenues for treating Type 2 diabetes, obesity, and cardiovascular disease.

该项目将研究一种名为CaMKK2的酶的调节，这种酶在控制许多重要的生物功能方面起着关键作用，包括大脑发育、食欲调节、能量代谢和血压。了解这种酶是如何被调节的，可能会为治疗2型糖尿病、肥胖和心血管疾病开辟新的途径。