Metabolic stress sensing by AMPK: implications for energy balance and isoform-targetting therapeutics

AMPK 的代谢应激传感：对能量平衡和异构体靶向治疗的影响

• 批准号: nhmrc : 1049197
• 负责人: Dr John Scott
• 金额: $ 42.15万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metabolic-stress-sensing-targetting-therapeutics/112067
• 关键词: Metabolic; stress; sensing; AMPK; implications

Metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease impose enormous medical and economic burdens on Western societies. Our research is focussed on the enzyme AMP-activated protein kinase (AMPK) which acts as the fuel gauge of the cell and is a promising drug target for combating metabolic diseases. Our discoveries provide critical insight on how AMPK is switched on by both energy demand and drugs, and will greatly assist development of AMPK-targetted therapeutics.

肥胖、2型糖尿病和心血管疾病等代谢性疾病给西方社会带来了巨大的医疗和经济负担。我们的研究主要集中在AMP激活的蛋白激酶（AMPK）上，AMPK作为细胞的燃料计量器，是对抗代谢疾病的有前途的药物靶点。我们的发现提供了关于AMPK如何通过能量需求和药物开启的关键见解，并将大大有助于AMPK靶向治疗的开发。