Uncovering New Mechanisms of Metabolite-Sensing and Signaling

该项目旨在了解细胞如何感知代谢活动的变化，以确保能量需求与营养供应相匹配。我们的建议将填补我们对新陈代谢感觉背后的分子机制的理解的关键空白。这将为澳大利亚依赖生物繁殖和利用的行业产生具有深远潜力的新知识，包括农业、生物技术和酿酒，以及与运动表现和衰老的代谢方面有关的知识。该项目将支持对早期职业研究人员和博士生的高级培训，这将扩大澳大利亚的研究能力，并为培养一支高技能的劳动力做出贡献。

This project aims to understand how cells sense changes in metabolic activity, to ensure energy demands are matched with nutrient supply. Our proposal will fill critical gaps in our understanding of the molecular mechanisms underlying metabolic sensing. This will generate new knowledge with far reaching potential for Australian industries that rely on the propagation and utilization of living organisms, including agriculture, biotechnology and brewing, as well as knowledge relevant to sporting performance and the metabolic dimensions of ageing. This project will support advanced training of early career researchers and PhD students, which will expand Australian research capabilities and contribute to a producing a highly skilled workforce.