Functional probiotic foods to enhance disease treatment and prevention

人们对天然保健产品的需求不断增加，加拿大每个月都有新的功能性食品问世。然而，证实这些食物和补充剂对健康有益的科学和临床数据有限。发展最快的领域之一是益生菌。我们假设乳酸菌和双歧杆菌菌株具有调节炎症和感染过程的能力，如果这些生物体或其活性副产物被正确利用，它们可以提供新的方法来缓解困扰许多加拿大人的疾病。本提案的总体目标：生成适合于生产具有免疫调节（抗炎和抗病毒）特性的功能性食品或膳食补充剂以及具有抗菌和增强抗生素效力的益生菌的科学数据。2.将这些技术转让给加拿大公司。3.培养至少5名博士科学家和10名本科生在快速发展的益生菌领域工作。本文提出的研究为加拿大成为利用细菌及其副产品解决该国面临的几个主要健康问题（即病毒和细菌感染以及慢性炎症）方面的领先者提供了坚实的基础。这笔拨款不仅将为拟议的研究提供关键的基础设施支持，还将为私营和公共部门的研发、食品和生物技术制造、市场营销、销售以及监管和教学职位提供培训人才。基础科学和应用科学将是功能食品和天然保健品产业蓬勃发展的基础。

There has been an ever-increasing demand for natural health products and each month in Canada new functional foods are introduced. However, there are limited scientific and clinical data to validate the health benefits of these foods and supplements. One of the fastest growing areas is probiotics. We hypothesize that strains of Lactobacillus and Bifidobacterium have the ability to modulate inflammatory and infectious processes, and if these organisms or their active by-products are harnessed correctly, they can provide new ways to alleviate conditions that afflict many Canadians. Overall objectives of this proposal: 1 .Generate the scientific data suitable for the creation of functional foods or dietary supplements that have immune modulation (anti-inflammatory, and anti-viral) properties and probiotics that are anti-bacterial and augment the potency of antibiotics. 2.Transfer these technologies to Canadian companies. 3.Train at least 5 PhD scientists and 10 undergraduate students to work in the rapidly expanding area of probiotics. The studies proposed herein, provide a strong basis for Canada to become a leader in the application of bacteria and their by-products to several of the leading health problems facing the country: namely, viral and bacterial infections, and chronic inflammatory conditions. The grant will provide critical infrastructure support for not only the studies proposed, but also to expand the pool of trained personnel for future roles in private and public sector R&D, food and biotech manufacturing, marketing, sales, and regulatory and teaching positions. Basic and applied science will be the foundation for a thriving functional food and natural health product industry.