Encapsulation for improved manufacturing and controlled-delivery of therapeutic compounds

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In the development of an effective therapeutic product, the synthesis and purification of the drug are only part of the process. It is also important to consider how the drug will be delivered. Liposomes or lipid vesicles are an attractive delivery system for administering functional compounds. Liposomal systems are known to increase drug retention time and to reduce toxic side effects after administration. One area of great interest is the use of liposomes in drug delivery systems administered by inhalation for a targeted, sustained and non-invasive means of delivering drugs to the lungs. The microencapsulation of liposome-entrapped compounds in biodegradable capsules offers a possible means of drug delivery to the lungs with increased stability and drug retention. This research has the potential for treating diseases such as tuberculosis and diabetes more effectively and without painful injections. Such benefits will undoubtedly improve the health and quality of life of the many Canadians who suffer from such diseases.