High-pressure homogenizer for the creation of liposomes and amulsions

从研究工具和仪器拨款中购买的高压均质机/挤出机系统将支持达尔豪斯大学三名研究人员的活动，他们的工作领域涉及药品，海洋提取物和食品安全。该设备可用于生产具有优异性能的脂质体和乳剂，并可用于细胞破坏。将得到支持的药物研究涉及生产微囊化脂质体药物颗粒，目的是提高肺给药的稳定性和控释特性。此外，脂质体的制备对于研究海洋阳离子抗菌肽及其对食品相关细菌的影响具有重要意义。高压均质机还将用于从细菌中提取酶，这些酶具有分解麻痹性贝类毒素的能力。它还将用于研究将化学修饰的抗菌肽（从鲱鱼奶中提取）纳入食品的潜力。

The high pressure homogenizer/extruder system to be purchased from this Research Tools and Instruments grant will support the activities of three researchers at Dalhousie University, working in areas relating to pharmaceuticals, marine extracts and food safety.  This equipment can be used to produce liposomes and emulsions with superior properties and for cell disruption.   The pharmaceutical research that will be supported involves the production of microencapsulated liposomal drug particles with the aim of improving stability and controlled-release properties for pulmonary delivery.  In addition, liposomal preparation will be important for the study of marine cationic antimicrobial peptides and their effects on food-related bacteria.  The high pressure homogenizer will also be used to extract enzymes from bacteria that have the ability to break down paralytic shellfish toxins.  It will also be used to study the potential for incorporating a chemically-modified antimicrobial peptide (extracted from herring milt) into food.