Digitized point-of-care diagnostics: Reading disc-based bioassays with a standard computer drive

数字化现场护理诊断：使用标准计算机驱动器读取基于光盘的生物测定结果

• 批准号: 356591-2007
• 负责人: Yu, HuaZhong
• 金额: $ 4.32万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=403003
• 关键词: Digitized; point; care; diagnostics; Reading

Microarray technology is a powerful tool for high-throughput analysis of biomolecular interactions, which is important for gene profiling, immunoassays, and drug discovery. However, its application is currently restrictec to biomedical laboratories or hospital settings with extensive infrastructure (e.g., robotic spotter, fluorescence scanner). Compact disc (CD)-based biomolecular screening is a promising, inexpensive alternative, especially suitable for point-of-care clinical diagnostics (e.g., in a doctor's office or remote areas). The direct adaptation of standard desktop/laptop computers and accessories for rapid biomedical diagnosis would constitute a major breakthrough in the field of health research: the optical drive can serve as detector and the plastic CD/DVD base as platform for the preparation of binding assays.

微阵列技术是高通量分析生物分子相互作用的有力工具，对于基因分析、免疫分析和药物发现具有重要意义。然而，其应用目前仅限于生物医学实验室或具有广泛基础设施的医院环境（例如，自动点样仪、荧光扫描仪）。基于光盘（CD）的生物分子筛选是一种有前途的、廉价的替代方案，特别适用于护理点临床诊断（例如，在医生的办公室或偏远地区）。将标准台式/膝上型计算机及其配件直接用于快速生物医学诊断将是卫生研究领域的一项重大突破：光驱可用作检测器，塑料CD/DVD底座可用作制备结合试验的平台。