Replacement tabletop ultracentrifuge

替换台式超速离心机

• 批准号: 359762-2008
• 负责人: Trimble, William
• 金额: $ 5.81万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=403727
• 关键词: Replacement; tabletop; ultracentrifuge

Ultracentrifugation involves the separation of different sized particles by very high centrifugal forces. This technique is fundamental to modern biology and requires a dedicated machine capable of achieving such high forces. Most laboratories in the fields of cell biology and biochemistry use this technique routinely and these machines are in very high demand. Tabletop ultracentrifuges are specifically designed to separate small samples and achieve remarkably high separation forces. We previously had a tabletop ultracentrifuge but this machine was more than 15 years old and is now obsolete. During its last breakdown the service representative indicated that the parts were no longer available for its repair and that it would need to be replaced. Our group of investigators is currently traveling to other buildings to perform ultracentrifugation, but the problem associated with this is not only the travel time and the difficulty booking time on other people's equipment. The major problems are that samples can be degraded if not used promptly after separation, and in some cases the materials that were separated can become remixed during travel. The current application is therefore to seek a replacement for this machine that can be housed in space central to our laboratories.

超离心是用很高的离心力分离不同大小的颗粒。这项技术是现代生物学的基础，需要一台能够实现如此高的力的专用机器。细胞生物学和生物化学领域的大多数实验室都经常使用这种技术，这些机器的需求量很大。台式超离心机是专门为分离小样品而设计的，可实现非常高的分离力。我们以前有一台台式超离心机，但这台机器已经超过15年了，现在已经过时了。在最后一次故障时，服务代表表示，该部件已无法维修，需要更换。我们的调查小组目前正在前往其他建筑物进行超离心，但与此相关的问题不仅是旅行时间和难以预订其他人设备的时间。主要的问题是，如果分离后不及时使用，样品可能会降解，并且在某些情况下，分离的材料可能在运输过程中重新混合。因此，目前的申请是寻找一种可以安置在我们实验室中心空间的机器的替代品。