Structural basis for targeting Wnt signalling pathway in cancer

细胞通过激活不同的信号通路来感知和响应各种刺激。Wnt通路在胚胎发育中很重要，因为它控制着细胞的分裂和特化。在成年人中，这一途径的失调可能导致细胞分裂异常和癌症。这项提议将使用结构生物学在分子水平上研究这一途径的几个步骤。这将为这一途径是如何工作的提供答案，并将导致针对它的治疗的新方法。

Cells sense and respond to a variety of stimuli by activating different signaling pathways. The Wnt pathway is important in embryonic development as it controls cell division and specialization. In adults, dysregulation of this pathway can lead to aberrant cell division and cancer. This proposal will use structural biology to look at several steps of this pathway at the molecular level. This will provide answers on how this pathway works and will lead to new ways to target it therapeutically.