Structural and functional studies on Leptospiral antigens central to pathogenesis

发病机制中重要的钩端螺旋体抗原的结构和功能研究

• 批准号: nhmrc : 519572
• 负责人: Dr Julian Vivian
• 金额: $ 19.16万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-functional-studies-central-pathogenesis/115741
• 关键词: Structural; functional; studies; Leptospiral; antigens

Leptospirosis, also known as Weil's disease and canefield fever, is a potentially fatal disease caused by infection with the bacteria Leptospira. Leptospira is able to infect a broad range of animals including livestock and humans. Human infection typically occurs through contact with water or vegetation that has been exposed to the urine of an infected animal. This project focuses on a key step in the bacterial infection in trying to understand how these bacteria adhere to human cells.

钩端螺旋体病，也被称为韦伊病和坎菲尔德热，是一种由钩端螺旋体感染引起的潜在致命疾病。钩端螺旋体能够感染包括牲畜和人类在内的多种动物。人类感染通常是通过接触接触过受感染动物尿液的水或植物而发生的。该项目的重点是细菌感染的关键步骤，试图了解这些细菌如何粘附在人体细胞上。