The molecular basis of HLA-linked drug hypersensivity reactions
The molecular basis of HLA-linked drug hypersensivity reactions
批准号:
nhmrc : 1063829
负责人:
Dr Julian Vivian
金额:
$45.55万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
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英文摘要
Adverse drug reactions are one of the leading causes of death in hospitalised patients. We have discovered a new mechanism that links these reactions to recognition of drug induced changes in immunological self, resulting from interactions of drugs with immune receptors. This project probes the generality of this mechanism by examining the basis of life threatening reactions to drugs used to treat epilepsy (carbamazepine), gout (allopurinol), HIV (Nevirapine) and towards aspirin a commonly used pharmaceutical.
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The molecular basis of HLA-linked drug hypersensitivity
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批准号:nhmrc : GNT1122099
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项目类别:Project Grants
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资助金额:$82.75万
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财政年份:2017
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负责人:Dr Julian Vivian
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依托单位:
Structure-function of type I interferon receptors: informing the basis for selective modulation of signal transduction and function
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批准号:nhmrc : 1126524
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项目类别:Project Grants
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资助金额:$89.98万
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财政年份:2017
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负责人:Dr Julian Vivian
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依托单位:
Structure-function of type I interferon receptors: informing the basis for selective modulation of signal transduction and function
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批准号:nhmrc : GNT1126524
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项目类别:Project Grants
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资助金额:$131.62万
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财政年份:2017
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负责人:Dr Julian Vivian
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依托单位:
The molecular basis of HLA-linked drug hypersensitivity
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批准号:nhmrc : 1122099
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项目类别:Project Grants
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资助金额:$56.55万
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财政年份:2017
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负责人:Dr Julian Vivian
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依托单位:
Structural and functional investigation of Killer-Cell Immunoglobulin-like receptors
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批准号:nhmrc : 1099814
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项目类别:Project Grants
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资助金额:$37.5万
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财政年份:2016
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负责人:Dr Julian Vivian
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依托单位:
Structural and functional investigation of Killer-Cell Immunoglobulin-like receptors
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批准号:nhmrc : GNT1099814
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项目类别:Project Grants
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资助金额:$54.7万
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财政年份:2016
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负责人:Dr Julian Vivian
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依托单位:
Structural and functional characterisation of the Killer cell Immunoglobulin-like Receptor (KIR) Family of Natural Killer Cell Receptors
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批准号:nhmrc : 1046685
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项目类别:Project Grants
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资助金额:$23.21万
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财政年份:2013
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负责人:Dr Julian Vivian
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依托单位:
An investigation into evolution and diversity within an innate immune recognition system
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批准号:DE130101504
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项目类别:Discovery Early Career Researcher Award
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资助金额:$27.36万
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财政年份:2013
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负责人:Dr Julian Vivian
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依托单位:
Structural and functional studies on Leptospiral antigens central to pathogenesis
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批准号:nhmrc : 519572
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项目类别:Early Career Fellowships
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资助金额:$19.16万
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财政年份:2008
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负责人:Dr Julian Vivian
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依托单位:
国内基金
海外基金
基于Volatility Basis-set方法对上海大气二次有机气溶胶生成的模拟
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批准号:41105102
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2011
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负责人:王杨君
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依托单位:
求解Basis Pursuit问题的数值优化方法
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批准号:11001128
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项目类别:青年科学基金项目
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资助金额:18.0万元
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批准年份:2010
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负责人:王丽平
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依托单位:
TB方法在有机和生物大分子体系计算研究中的应用
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批准号:20773047
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项目类别:面上项目
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资助金额:26.0万元
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批准年份:2007
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负责人:吕文彩
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依托单位: