Structure-function of type I interferon receptors: informing the basis for selective modulation of signal transduction and function

I型干扰素受体的结构-功能：为选择性调节信号转导和功能奠定基础

• 批准号: nhmrc : 1126524
• 负责人: Dr Julian Vivian
• 金额: $ 89.98万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-type-transduction-function/947806
• 关键词: Structure; function; type; interferon; receptors

Interferons (IFNs) are a family of proteins with critical roles in infectious and inflammatory diseases and cancers. Currently we do not understand why there are so many type I IFNs, their different functions and how they are achieved. This project will determine at a fine molecular level how different IFNs interact with molecules on target cells and transmit particular signals. We will focus on a novel IFN? that we discovered. These studies will underpin the development of new therapies.

干扰素（IFN）是在感染性和炎性疾病和癌症中具有关键作用的蛋白质家族。目前，我们不明白为什么有这么多的I型干扰素，它们的不同功能以及它们是如何实现的。该项目将在精细分子水平上确定不同的IFN如何与靶细胞上的分子相互作用并传递特定信号。我们将集中在一个新的干扰素？我们发现的。这些研究将支持新疗法的开发。