The molecular basis of HLA-linked drug hypersensitivity

HLA相关药物超敏反应的分子基础

• 批准号: nhmrc : 1122099
• 负责人: Dr Julian Vivian
• 金额: $ 56.55万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-hla-drug-hypersensitivity/946867
• 关键词: molecular; basis; HLA; linked; drug

Adverse drug reactions are one of the leading causes of death in hospitalised patients. We discovered a new mechanism that links these reactions to recognition of drug induced changes in immunological self, resulting from interactions of drugs with immune receptors. This project continues to probe the mechanisms of immune mediated drug reactions by examining the basis of life threatening reactions to drugs used to treat epilepsy, gout and commonly used drugs such as penicillin and aspirin.

药物不良反应是住院患者死亡的主要原因之一。我们发现了一种新的机制，将这些反应与药物诱导的自身免疫变化的识别联系起来，这些变化是由药物与免疫受体的相互作用引起的。该项目通过检查用于治疗癫痫、痛风和常用药物（如青霉素和阿司匹林）的危及生命的反应的基础，继续探索免疫介导的药物反应的机制。