Structural investigation into the regulation of the colony stimulating factor receptor, c-FMS.

集落刺激因子受体 c-FMS 调节的结构研究。

• 批准号: nhmrc : 519566
• 负责人: Dr Mark Walter
• 金额: $ 19.16万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-investigation-regulation-c-fms/115740
• 关键词: Structural; investigation; into; regulation; colony

The colony stimulating factor receptor, c-FMS is a member of a family of protein signalling molecules expressed on the cell surface that are implicated in the development of serious diseases in humans, such as inflammatory diseases and cancer. A number of important proteins bind to and regulate c-FMS in different ways. I intend to visualise these interactions to further understand how c-FMS activity is controlled by alternative means.

集落刺激因子受体 c-FMS 是细胞表面表达的蛋白质信号分子家族的成员，这些分子与人类严重疾病（例如炎症性疾病和癌症）的发展有关。许多重要的蛋白质以不同的方式结合并调节 c-FMS。我打算将这些相互作用可视化，以进一步了解 c-FMS 活动是如何通过替代方式控制的。