A structural investigation into T cell signalling machines

T 细胞信号传导机制的结构研究

• 批准号: DP170103822
• 负责人: Prof Jamie Rossjohn
• 金额: $ 38.95万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-09 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170103822
• 关键词: structural; investigation; into; cell; signalling

The project aims to understand how receptor recognition events cause intracellular signalling.Membrane-bound receptors, their cognate ligands and the ensuing intracellular activation signal determine cellular fate. The project will explore events central to cellular immunity by examining the T cell signalling machinery. This project will use labelling, crystallographic and cryo-electron microscopy studies, to determine the molecular architecture of the T cell receptor (TCR) CD3 complex, a molecular machine central to T cell signalling. This project should reveal how antigen recognition leads to T cell signal transduction which will create jobs, bring substantial health benefits and improve quality of life for Australians.

该项目旨在了解受体识别事件如何引起细胞内信号传导。膜结合受体，其同源配体和随后的细胞内激活信号决定细胞命运。该项目将通过检查T细胞信号机制来探索细胞免疫的核心事件。该项目将使用标记，晶体学和冷冻电子显微镜研究，以确定T细胞受体（TCR）CD3复合物的分子结构，这是T细胞信号传导的分子机器。该项目将揭示抗原识别如何导致T细胞信号转导，这将创造就业机会，带来实质性的健康益处，并提高澳大利亚人的生活质量。