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A structural investigation into T cell signalling machines

A structural investigation into T cell signalling machines
T 细胞信号传导机制的结构研究
批准号:
DP170103822
负责人:
Prof Jamie Rossjohn
金额:
$38.95万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-09 至 2019-12-31

项目摘要

项目成果

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中文摘要
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英文摘要
The project aims to understand how receptor recognition events cause intracellular signalling.Membrane-bound receptors, their cognate ligands and the ensuing intracellular activation signal determine cellular fate. The project will explore events central to cellular immunity by examining the T cell signalling machinery. This project will use labelling, crystallographic and cryo-electron microscopy studies, to determine the molecular architecture of the T cell receptor (TCR) CD3 complex, a molecular machine central to T cell signalling. This project should reveal how antigen recognition leads to T cell signal transduction which will create jobs, bring substantial health benefits and improve quality of life for Australians.
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海外基金