Structure and Function of the HCV glycoproteins

HCV 糖蛋白的结构和功能

• 批准号: nhmrc : 603735
• 负责人: A/Pr Fasseli Coulibaly
• 金额: $ 39.93万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-hcv-glycoproteins/96584
• 关键词: Structure; Function; HCV; glycoproteins

Hepatitis C Virus infects 3% of the world's population causing recurring liver disease, cirrhosis and hepatocellular carcinoma. To infect a liver cell, the viral glycoproteins attach to cell surface molecules wher they are activated to mediate merger of the viral and cellular membranes. This project grant will explore how the viral glycopropteins become activated and obtain essential structural information on the viral glycoproteins. These studies will help us to design antiviral agents.

丙型肝炎病毒感染了世界上3%的人口，导致复发性肝病、肝硬化和肝细胞癌。为了感染肝细胞，当病毒糖蛋白被激活时，它们附着在细胞表面分子上，介导病毒和细胞膜的合并。该项目将探索病毒糖蛋白如何被激活并获得病毒糖蛋白的基本结构信息。这些研究将有助于我们设计抗病毒药物。