Structural analysis of poxvirus immature particles and spheroids

痘病毒未成熟颗粒和球体的结构分析

• 批准号: nhmrc : 545995
• 负责人: A/Pr Fasseli Coulibaly
• 金额: $ 25.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-analysis-poxvirus-particles-spheroids/115913
• 关键词: Structural; analysis; poxvirus; immature; particles

Despite the eradication of smallpox by vaccination, poxviruses remain a threat to public health because of bioterrorist scares from kept variola stocks and because of the possible emergence of other poxvirus pathogens from the extensive animal reservoir. The structural analysis of the assembly of poxvirus will not only improve our knowledge of fundamental processes, highly conserved in DNA viruses, but could also provide valuable targets for the rational design of antiviral drugs.

尽管通过接种疫苗根除了天花，但由于饲养的天花种群产生的生物恐怖恐慌，以及可能从广泛的动物宿主中出现其他痘病毒病原体，痘病毒仍然对公众健康构成威胁。对痘病毒组装的结构分析不仅可以提高我们对DNA病毒高度保守的基本过程的认识，而且可以为抗病毒药物的合理设计提供有价值的靶点。