Understanding the role of the scaffolding protein D13 in poxvirus assembly and its inhibition by rifampicin

了解支架蛋白 D13 在痘病毒组装中的作用及其利福平的抑制作用

• 批准号: nhmrc : 1051907
• 负责人: A/Pr Fasseli Coulibaly
• 金额: $ 24.76万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-scaffolding-inhibition-rifampicin/112250
• 关键词: Understanding; role; scaffolding; protein; D13

Smallpox is one the most notorious diseases in human history. Despite its eradication in the 1970s, human cases of animal poxviruses such as monkeypox virus and the potential use of smallpox as a bioterrorism weapon have called for an improved preparedness of Australia against (re)-emerging poxviruses. This project combines structural biology approaches to understand the complex assembly of poxviruses and provide the basis for the development of broad-spectrum antiviral drugs.

天花是人类历史上最臭名昭著的疾病之一。尽管在20世纪70年代已被根除，但动物痘病毒（如猴痘病毒）的人类病例以及天花作为生物恐怖主义武器的潜在用途要求澳大利亚加强对（重新）出现的痘病毒的准备。该项目结合结构生物学方法来了解痘病毒的复杂组装，并为开发广谱抗病毒药物提供基础。