Studies on the expression of muscarinic receptors: Implications for the pathology of schizophrenia

毒蕈碱受体表达的研究：对精神分裂症病理学的影响

• 批准号: nhmrc : 509333
• 负责人: A/Pr Elizabeth Scarr
• 金额: $ 33.26万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-expression-muscarinic-pathology-schizophrenia/80725
• 关键词: Studies; expression; muscarinic; receptors; Implications

Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. This project will help define changes in the molecules in the brain of subjects with schizophrenia which are likely to be involved in two symptoms of the disorder, the psychoses and cognitive deficits. Understanding the cause of the cognitive deficits of schizophrenia is a high priority because they are the most disabilitating symptom of the disorder and do not respond to current drug treatments.

精神分裂症是一种严重的精神疾病，影响大约 1% 的人口。该项目将帮助确定精神分裂症患者大脑中分子的变化，这些变化可能与该疾病的两种症状（精神病和认知缺陷）有关。了解精神分裂症认知缺陷的原因是当务之急，因为它们是该疾病最严重的症状，并且对当前的药物治疗没有反应。