A Breakdown of Cortical Homeostasis in Depression: A Focus on the Anterior Cingulate

抑郁症中皮质稳态的崩溃：关注前扣带回

• 批准号: nhmrc : 1105332
• 负责人: A/Pr Elizabeth Scarr
• 金额: $ 42.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/breakdown-cortical-homeostasis-anterior-cingulate/662822
• 关键词: Breakdown; Cortical; Homeostasis; Depression; Focus

Major depressive disorders affect 20% of the Australian population. Some symptoms of major depressive disorders arise because of a dysfunction of the human brain, particularly the cortex. Our studies show there are biochemical changes in the anterior cingulate cortex in people with mood disorders. We will now extend our studies to show there is a breakdown in the balance between neurotransmitter and neuroinflammation pathways in the anterior cingulate cortex in major depressive disorders.

重度抑郁症影响了20%的澳大利亚人口。重度抑郁症的一些症状是由于人类大脑，特别是皮层的功能障碍而出现的。我们的研究表明，情绪障碍患者的前扣带皮层会发生生化变化。我们现在将扩展我们的研究，以证明在重度抑郁症的前扣带皮层中，神经递质和神经炎症通路之间的平衡被打破。