Muscarinic receptors in the human brain: In health and in sickness

人脑中的毒蕈碱受体：健康和疾病时

• 批准号: nhmrc : 1045619
• 负责人: A/Pr Elizabeth Scarr
• 金额: $ 26.3万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/muscarinic-receptors-human-health-sickness/111772
• 关键词: Muscarinic; receptors; human; brain; health

Schizophrenia is a severe mental illness, with sub-optimal treatment outcomes. New drugs are being designed to provide more effective treatment. To understand the effects of these drugs, we need to know which brain cells have the protein these new drugs target and which cells are affected in schizophrenia. Our project will determine the localisation of this drug target; this knowledge will help the development of better treatments for schizophrenia.

精神分裂症是一种严重的精神疾病，治疗效果欠佳。正在设计新的药物以提供更有效的治疗。为了了解这些药物的效果，我们需要知道哪些脑细胞有这些新药靶向的蛋白质，哪些细胞在精神分裂症中受到影响。我们的项目将确定该药物靶点的定位；这些知识将有助于开发更好的精神分裂症治疗方法。