Differential Changes in Cortical Tumour Necrosis Factor Signalling in Mood Disorders and Schizophrenia

情绪障碍和精神分裂症中皮质肿瘤坏死因子信号传导的差异变化

• 批准号: nhmrc : 1066144
• 负责人: A/Pr Elizabeth Scarr
• 金额: $ 42.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/differential-changes-cortical-disorders-schizophrenia/455220
• 关键词: Differential; Changes; Cortical; Tumour; Necrosis

Changes in inflammation-related pathways contribute to the symptoms of psychiatric disorders and tumour necrosis factor ? (TNF) is a protein central to regulating theses pathways. We have now shown that changes in pathways regulated by TNF are present in the brains of people with schizophrenia and mood disorders. This means that the symptoms experienced by those with the different disorders may be linked to differential changes in TNF-regulated pathways in the brain.

炎症相关通路的改变导致精神疾病的症状和肿瘤坏死因子？(TNF)是调节这些通路的核心蛋白质。我们现在已经表明，TNF调节的途径的变化存在于精神分裂症和情绪障碍患者的大脑中。这意味着那些患有不同疾病的人所经历的症状可能与大脑中TNF调节途径的差异变化有关。