Differential Changes in Cortical Tumour Necrosis Factor Signalling in Mood Disorders and Schizophrenia

炎症相关通路的改变导致精神疾病的症状和肿瘤坏死因子？(TNF)是调节这些通路的核心蛋白质。我们现在已经表明，TNF调节的途径的变化存在于精神分裂症和情绪障碍患者的大脑中。这意味着那些患有不同疾病的人所经历的症状可能与大脑中TNF调节途径的差异变化有关。

Changes in inflammation-related pathways contribute to the symptoms of psychiatric disorders and tumour necrosis factor ? (TNF) is a protein central to regulating theses pathways. We have now shown that changes in pathways regulated by TNF are present in the brains of people with schizophrenia and mood disorders. This means that the symptoms experienced by those with the different disorders may be linked to differential changes in TNF-regulated pathways in the brain.