Surface tension of upper airway lining liquid: role in obstructive sleep apnoea hyponoea syndrome

上呼吸道内层液体的表面张力：在阻塞性睡眠呼吸暂停低通气综合征中的作用

• 批准号: nhmrc : 402654
• 负责人: A/Pr Terence Amis
• 金额: $ 33万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/surface-tension-upper-hyponoea-syndrome/96976
• 关键词: Surface; tension; upper; airway; lining

The obstructive sleep apnoea hypopnoea syndrome (OSAHS) refers to a condition in which throat blockage occurs during sleep leading to breathing difficulties, including cessation of breathing for short periods of time. OSAHS affects both men and women but is amongst the commonest of chronic disorders of adult males, occurring in 5% of men over the age of 45 years. In the proposed studies we will examine the effect that the liquid layer that lines the throat, has on the ability of the airway to stay open during sleep. In particular we will examine whether coating the throat with a substance that decreases stickiness will help to prevent the occurrence of episodes of throat blockage during sleep in persons with OSAHS. We will also explore the role of saliva production and swallowing during sleep in maintaining a low stickiness of the throat and whether this liquid lining is abnormal in OSAHS patients. These studies will establish the potential usefulness of decreasing the stickiness of the liquid lining the throat as a treatment for OSAHS.

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是指睡眠中喉咙堵塞导致呼吸困难，包括短时间呼吸停止的一种情况。OSAHS对男性和女性都有影响，但它是成年男性最常见的慢性疾病之一，发生在45岁以上男性的5%。在拟议的研究中，我们将检查喉咙内的液体层对呼吸道在睡眠期间保持开放的能力的影响。特别是，我们将研究在喉咙上涂上一种降低粘性的物质是否有助于防止OSAHS患者在睡眠期间发生喉咙堵塞。我们还将探讨睡眠时唾液分泌和吞咽在维持喉咙低粘性中的作用，以及这种液体衬里在OSAHS患者中是否异常。这些研究将确定降低喉部液体衬里的粘性作为治疗OSAHS的潜在有用之处。