THE VASCULAR CONSEQUENCES OF SNORING AND OBSTRUCTIVE SLEEP APNOEA

打鼾和阻塞性睡眠呼吸暂停的血管后果

• 批准号: nhmrc : 211245
• 负责人: A/Pr Terence Amis
• 金额: $ 31.74万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vascular-consequences-snoring-sleep-apnoea/97381
• 关键词: VASCULAR; CONSEQUENCES; SNORING; OBSTRUCTIVE; SLEEP

Snoring refers to a condition where the throat narrows significantly during sleep, and allows the soft tissues which surround this part of the airway to vibrate and create the typical snoring noise. Habitual snoring is a very common problem in the adult population, with a prevalence of between 20-40%. More severe forms of snoring are associated with the obstructive sleep apnoea syndrome, which is a condition in which the throat completely blocks behind the tongue and palate during sleep leading to cessation of breathing for short periods of time. Sleep apnoea is among the commonest chronic disorders of adult males occurring in 5% of men over the age of 45 years. Increasingly, it is now recognised that snoring, without sleep apnoea, may be an independent risk factor for the development of both of these very common and significant medical disorders. However, there have been no studies exploring the mechanisms by which snoring might contribute to the development of stroke and hypertension. In this proposal, we will explore the hypothesis that chronic snoring transmits a pressure wave through the tissues of the neck to the carotid artery which is the main blood supply to the brain. We propose that the chronic vibration of this artery leads to disease such as atherosclerosis and hypertension. Our studies will help to prove that this is a common mechanism whereby both snoring and sleep apnoea may contribute to the development of important vascular diseases. Studies will also establish the prevalence of carotid atherosclerosis in snorers (with and without OSA), and the prevalence of habitual snoring and OSA in patients at risk of developoing completed stroke. The recognition of snoring as an independent risk factor for vascular disease will clearly have important and wide ranging implications for the future management of snoring in the prevention of stroke and hypertension.

鼾症指的是睡眠期间喉咙明显变窄，导致这部分呼吸道周围的软组织振动，产生典型的鼾声。习惯性打鼾症在成年人中是一个非常普遍的问题，患病率在20%-40%之间。更严重的鼾症与阻塞性睡眠呼吸暂停综合征有关，这是一种在睡眠时喉咙完全堵塞在舌头和上颚后面，导致呼吸短暂停止的情况。睡眠呼吸暂停是成年男性最常见的慢性疾病之一，发生在45岁以上男性的5%。现在越来越多的人认识到，没有睡眠呼吸暂停的打鼾症可能是这两种非常常见和严重的医疗疾病发展的一个独立的风险因素。然而，还没有研究探讨打鼾症可能导致中风和高血压的机制。在这项提案中，我们将探索一种假设，即慢性鼾症将压力波通过颈部组织传递到颈动脉，颈动脉是大脑的主要血液供应。我们认为这条动脉的慢性振动会导致动脉粥样硬化和高血压等疾病。我们的研究将有助于证明，这是一种共同的机制，打鼾症和睡眠呼吸暂停可能有助于重要血管疾病的发展。研究还将确定打鼾者(有无阻塞性睡眠呼吸暂停)中颈动脉粥样硬化的患病率，以及有发生完全性中风风险的患者中习惯性打鼾症和阻塞性睡眠呼吸暂停的发生率。认识到鼾症是血管疾病的一个独立危险因素，显然将对未来在预防中风和高血压方面对鼾症的管理具有重要和广泛的影响。