THE BAROREFLEX IN SNORING AND THE OBSTRUCTIVE SLEEP APNOEA HYPOPNOEA SYNDROME

打鼾和阻塞性睡眠呼吸暂停低通气综合征中的压力反射

• 批准号: nhmrc : 402656
• 负责人: A/Pr Terence Amis
• 金额: $ 29.09万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/baroreflex-snoring-obstructive-hypopnoea-syndrome/96477
• 关键词: BAROREFLEX; SNORING; OBSTRUCTIVE; SLEEP; APNOEA

The obstructive sleep apnoea hypopnoea syndrome (OSAHS) refers to a condition in which throat blockage occurs during sleep leading to breathing difficulties, including snoring and cessation of breathing for short periods of time. OSAHS is amongst the commonest of chronic disorders of adult males, occuring in 5% of men over the age of 45 years. It is now recognised that one of the major complications of OSAHS is the development of high blood pressure and heart disease. In the proposed studies, we will examine the proposal that snoring alone, without significant associated OSAHS, can also lead to high blood pressure in habitual snorers both awake and asleep. In particular, we will explore the hypothesis that chronic snoring transmits a pressure wave through the tissues of the neck to the carotid artery which is the main blood supply to the brain. We propose that the chronic vibration of this artery can alter pressure sensors in the artery wall, which then results in the persistance of high blood pressure. Our studies will help to prove that this is a mechanism whereby both snoring and OSAHS may contribute to the development of high blood pressure. The recognition of snoring as an independent risk factor for high blood pressure will clearly have important and wide ranging implications for the future management of snoring in the prevention of high blood pressure.

阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是指睡眠时喉咙堵塞导致呼吸困难，包括打鼾和短时间呼吸停止的一种情况。OSAHS是成年男性中最常见的慢性疾病之一，在45岁以上的男性中发病率为5%。现在人们认识到，OSAHS的主要并发症之一是高血压和心脏病的发展。在拟议的研究中，我们将检查单独打鼾，没有明显相关的OSAHS，也会导致习惯性打鼾者在清醒和睡眠时高血压的提议。特别是，我们将探讨慢性打鼾通过颈部组织向颈动脉传递压力波的假设，颈动脉是大脑的主要血液供应。我们认为，这条动脉的长期振动可以改变动脉壁的压力传感器，从而导致高血压的持续存在。我们的研究将有助于证明这是一种机制，即打鼾和OSAHS都可能导致高血压的发展。认识到打鼾是高血压的一个独立危险因素，显然对未来管理打鼾预防高血压具有重要而广泛的意义。