Upgrade to a high performance liquid chromatography system for peptide and protein chemistry

升级至用于肽和蛋白质化学的高效液相色谱系统

• 批准号: 374636-2009
• 负责人: Rainey, Jan
• 金额: $ 2.88万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=411975
• 关键词: Upgrade; performance; liquid; chromatography; system

Protein molecules in a human body frequently interact with other molecules. Some of these intermolecular interactions are transient in nature allowing, for example, the transduction of a physiological signal, while others are practically permanent, giving rise to larger protein assemblies with defined functions. Although these types of interactions are ubiquitous and essential for many physiological processes, the actual mechanisms by which they occur are poorly understood. Furthermore, perturbations to these interactions occur under many disease conditions, often being directly implicated in progression of the disease.

人体内的蛋白质分子经常与其他分子相互作用。这些分子间相互作用中的一些在性质上是瞬时的，允许例如生理信号的转导，而其他的几乎是永久的，产生具有限定功能的较大蛋白质组装体。虽然这些类型的相互作用是普遍存在的，对许多生理过程是必不可少的，但它们发生的实际机制却知之甚少。此外，在许多疾病条件下发生对这些相互作用的扰动，通常直接涉及疾病的进展。