A circular dichroism spectropolarimeter

圆二色性分光偏振计

• 批准号: 375206-2009
• 负责人: Wu, Gang
• 金额: $ 8.56万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=412107
• 关键词: circular; dichroism; spectropolarimeter

Circular dichroism (CD) is a spectroscopic technique routinely used by chemists and biochemists to study the chirality of molecules. Chiral molecules or biomolecules (such as DNA and proteins) folded into a particular three-dimensional structure always exhibit characteristic spectral features in their CD spectra. Thus CD spectra provide crucial information about the chirality of the molecular system under investigation and are often treated as the fingerprint of the molecular system. These fingerprints are extremely important for structure identification. A CD spectropolarimeter is a must-have item in laboratories to study molecular chirality. The requested modern CD spectropolarimeter will provide new research capabilities such as simultaneous CD/fluorescence detection and automatic temperature scanning that are currently unavailable in the Chemistry Department at Queen's. With these enhanced capabilities, our research programs will be able to remain internationally competitive in the important areas of DNA structure and folding, DNA-based new luminescent materials, supramolecular chemistry, chiral polymers, and chiral photonics. This CD spectropolarimeter will also provide valuable training opportunities for graduate students and postdoctoral fellows so that they become familiar with modern analytical techniques that are routinely used in any biomedical research laboratory in both academic and industrial environments.

圆二色性（CD）是化学家和生物化学家经常使用的一种光谱技术，用于研究分子的手性。手性分子或生物分子（如DNA和蛋白质）折叠成特定的三维结构，在其CD光谱中总是表现出特征性的光谱特征。因此，CD光谱提供了关于所研究的分子系统的手性的关键信息，并且通常被视为分子系统的指纹。这些指纹对于结构鉴定非常重要。旋光分光光度计是实验室研究分子手性的必备仪器。所要求的现代CD分光偏振仪将提供新的研究能力，如同时CD/荧光检测和自动温度扫描，这是目前皇后大学化学系无法提供的。凭借这些增强的能力，我们的研究计划将能够在DNA结构和折叠，基于DNA的新型发光材料，超分子化学，手性聚合物和手性光子学等重要领域保持国际竞争力。该CD分光偏振仪还将为研究生和博士后研究员提供宝贵的培训机会，使他们熟悉在学术和工业环境中的任何生物医学研究实验室中常规使用的现代分析技术。