Urgent replacement of two NMR probes at Queen's NMR facility

这是NSERC资金的一项申请，用于更换皇后大学化学系核磁共振设施中两个老化的核磁共振探头。核磁共振光谱是一种强大的分析技术，化学家们每天都使用它来研究分子结构、动力学和化学键。探头是光谱仪的关键部件，主要负责核磁共振信号检测过程中的总体灵敏度。经过12年的服务，这两个有问题的核磁共振探测器的寿命即将结束。因此，近几个月来，它们的表现急剧恶化。这意味着研究人员必须花费更长的数据采集时间才能获得令人满意的结果。在某些情况下，两个老化探针的低灵敏度使研究人员无法检测到任何有用的核磁共振信号，从而阻碍了他们的研究进展。要求更换/升级用于多核核磁共振实验的两个老化的核磁共振探针不仅是必要的，而且是紧迫的。所要求的新的核磁共振探针将使92名研究人员受益，这些研究项目由NSERC支持，涉及女王学院多个系(化学、化学工程和生物化学)的30多个研究项目。由于多核核磁共振是化学和生物科学中许多研究领域不可或缺的工具，因此继续使用最先进的多核核磁共振设施对于我们多样化的研究项目保持国际竞争力至关重要。这些成功的研究计划的成果将从基础科学的进步到商业产品的开发。

This is an application for NSERC funds to replace two aging nuclear magnetic resonance (NMR) probes at the NMR Facility in the Department of Chemistry of Queen's University. NMR spectroscopy is a powerful analytical technique that chemists use daily to study molecular structure, dynamics, and chemical bonding. Probes are a critical component of a spectrometer and are primarily responsible for the overall sensitivity during detection of NMR signals. After 12 years of services, the two NMR probes in question are getting close to the end of their lifetimes. As a result, their performance has deteriorated drastically in recent months. This means that researchers must spend much longer data acquisition times to obtain satisfactory results. In some cases, the low sensitivity associated with the two aging probes has prevented researchers from detecting any useful NMR signals, thus hampering their research progress. The requested replacement/upgrade of the two aging NMR probes used for multi-nuclear NMR experiments is not only necessary but also urgent. The requested new NMR probes will benefit 92 researchers from more than 30 NSERC-supported research programs across several departments (Chemistry, Chemical Engineering, and Biochemistry) at Queen's. Because multi-nuclear NMR is an indispensable tool in many research fields in chemical and biological sciences, to have continuing access to the state-of-the-art multi-nuclear NMR facility is crucial for our diverse research programs to maintain competitiveness at the international level. The outcome of these successful research programs will range from advances in fundamental science to developments of commercial products.