Ultrasound imaging in reproductive science

生殖科学中的超声成像

• 批准号: 375327-2009
• 负责人: Adams, Gregg
• 金额: $ 4.48万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=412134
• 关键词: Ultrasound; imaging; reproductive; science

"Gray-scale, real-time ultrasonography is the most profound technological advance in the field of animal research and clinical reproduction since the introduction of transrectal palpation and radioimmunoassay." This is as true today as when it was first stated by pioneering reproductive physiologist, OJ Ginther in 1986. Ultrasonography provides a window through which we may view the internal form and function of the body instantly, repeatedly, and without disruption or deleterious effects. Ultrasonography has been employed in the study of reproductive events more than in any other field of study, and has revolutionized our understanding of ovarian follicle and luteal dynamics, ovulation, reproductive cycle endocrinology, embryo-uterine interactions, and the effects of treatments designed to improve or prevent conception. The bovine model of ovarian function is perhaps the most well-studied of any species, and discoveries of follicular wave patterns and the mechanism of selection of the dominant/ovulatory follicle have formed the basis of subsequent studies in many other species, including women. We have been at the forefront of this research. We will employ the use of portable, high-resolution ultrasound equipment to on-going studies of mechanisms controlling ovarian function in domestic species (e.g., bovine and camelid), and establish the normal characteristics of the reproductive cycle of wild threatened species (Wood bison, Northern fur seal). Studies will include computer-assisted analysis of 2- and 3-dimentional ultrasound images of ovarian follicles, corpora lutea and vascularity, to test the hypothesis that the physiologic stage and health of the reproductive cycle can be accurately assessed on the basis of a single ultrasound examination. Technological advances in ultrasound equipment have provided exciting opportunities to test this hypothesis using images acquired under strict laboratory settings, as well as those collected in the field. An investment in a new, state-of-the-art ultrasound system is needed at this time to ensure a position of pre-eminence that has been established as a result the applicants' NSERC-supported research programs.

“灰阶实时超声检查是自经直肠触诊和放射免疫测定以来动物研究和临床生殖领域最深刻的技术进步。“这在今天和1986年生殖生理学家先驱OJ Ginther首次提出时一样真实。超声波检查提供了一个窗口，通过它我们可以立即、重复地观察身体的内部形态和功能，而不会造成破坏或有害影响。超声检查在生殖事件的研究中的应用比任何其他研究领域都多，并且彻底改变了我们对卵泡和黄体动力学、排卵、生殖周期内分泌学、胚胎-子宫相互作用以及旨在改善或预防受孕的治疗效果的理解。牛的卵巢功能模型可能是所有物种中研究得最充分的，卵泡波模式和优势/排卵卵泡选择机制的发现已经成为许多其他物种（包括女性）的后续研究的基础。我们一直处于这项研究的前沿。我们将使用便携式高分辨率超声设备对控制家养物种卵巢功能的机制进行持续研究（例如，牛和骆驼），并建立野生濒危物种（伍德野牛，北方海狗）的生殖周期的正常特征。研究将包括对卵泡、黄体和血管的二维和三维超声图像的计算机辅助分析，以检验生殖周期的生理阶段和健康可以在单次超声检查的基础上准确评估的假设。超声设备的技术进步提供了令人兴奋的机会，使用在严格的实验室设置下获得的图像以及在现场收集的图像来测试这一假设。在一个新的，国家的最先进的超声系统的投资是需要在这个时候，以确保卓越的地位，已经建立了作为一个结果，申请人的NSERC支持的研究计划。