Systems genomics of childhood trajectories in immune development and asthma

免疫发育和哮喘儿童轨迹的系统基因组学

• 批准号: nhmrc : GNT1138424
• 负责人: A/Pr Michael Inouye
• 金额: $ 100.11万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/systems-genomics-childhood-development-asthma/1348145
• 关键词: Systems; genomics; childhood; trajectories; immune

Infant immune systems start at different competencies and mature at different rates. Little is known about this process and its effect on diseases such as asthma, allergy and respiratory infection. Using a prospective cohort, we aim to dissect the complexity of immune development in early life by characterizing its relationship with genetics, microbial colonization of the airways, and respiratory illness.

婴儿的免疫系统以不同的能力开始，以不同的速度成熟。人们对这一过程及其对哮喘、过敏和呼吸道感染等疾病的影响知之甚少。使用前瞻性队列，我们的目标是通过表征免疫发育与遗传学、呼吸道微生物定植和呼吸道疾病的关系来剖析早期生命免疫发育的复杂性。