Genomic risk of coeliac disease in first-degree relatives

一级亲属患乳糜泻的基因组风险

• 批准号: nhmrc : 1104165
• 负责人: A/Pr Michael Inouye
• 金额: $ 43.19万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomic-risk-coeliac-degree-relatives/662726
• 关键词: Genomic; risk; coeliac; disease; first

Coeliac disease is a common and strongly genetically determined inflammatory disorder triggered by gluten exposure. Because of its substantial genetic component, familial risk is substantial yet currently the actual risk is poorly quantified. We aim to use genomic profiling to construct and validate a novel risk score which can accurately determine which family members of coeliac disease cases are most at risk themselves.

乳糜泻是一种常见的和强烈的遗传决定炎症性疾病引发的麸质暴露。由于其大量的遗传成分，家族性风险是巨大的，但目前实际风险缺乏量化。我们的目标是使用基因组分析来构建和验证一种新的风险评分，该评分可以准确地确定哪些乳糜泻病例的家庭成员自己最有风险。