Evaluating the genetic contribution to rheumatic heart disease pathogenesis in Australian Aboriginal and Torres Strait Islander communities

评估澳大利亚原住民和托雷斯海峡岛民社区风湿性心脏病发病机制的遗传贡献

• 批准号: nhmrc : 1023462
• 负责人: A/Pr Michael Inouye
• 金额: $ 118.83万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evaluating-genetic-contribution-islander-communities/110279
• 关键词: Evaluating; genetic; contribution; rheumatic; heart

Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.

风湿性心脏病在澳大利亚土著人中非常普遍，并导致早期心脏病。尽管经过了数十年的研究，但其发生的潜在遗传机制仍不清楚。我们正在进行一项遗传研究，以更好地了解为什么有些人易患RHD，而另一些人则不然。这项研究将涉及土著居民的大量领导和协商，并将成为在土著居民中进行遗传研究的典范。