Integrative genomics and prediction of cardiovascular disease

综合基因组学和心血管疾病预测

• 批准号: nhmrc : 1062227
• 负责人: A/Pr Michael Inouye
• 金额: $ 51.13万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrative-genomics-prediction-cardiovascular-disease/454969
• 关键词: Integrative; genomics; prediction; cardiovascular; disease

Technologies that measure whole molecular systems are just beginning to reveal the complexity of living organisms and the underlying molecular networks that govern them. Cardiovascular diseases emerge out of these networks as a result of genetic and molecular perturbations. This project aims to characterize the role molecular networks play in cardiovascular disease risk as well as how they react to genetic risk factors. In doing so, it will identify potential therapeutics and personalized approaches to target pathogenesis.

测量整个分子系统的技术才刚刚开始揭示生物体的复杂性和控制它们的潜在分子网络。由于遗传和分子的扰动，心血管疾病从这些网络中出现。该项目旨在描述分子网络在心血管疾病风险中的作用，以及它们对遗传风险因素的反应。在此过程中，它将确定潜在的治疗方法和针对目标发病机制的个性化方法。