Dehydration of biological materials with radiant energy and vacuum

利用辐射能和真空对生物材料进行脱水

• 批准号: 36615-2009
• 负责人: Durance, Timothy
• 金额: $ 2.77万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=421020
• 关键词: Dehydration; biological; materials; radiant; energy

Radiant Energy Vacuum (REV) is technique for drying heat-sensitive materials very quickly but at low temperatures so as not to damage biological activity. Vacuum is employed to lower the boiling point of water to just above the freezing point or even to far below the freezing point, then microwaves are employed to quickly evaporate the water without raising the temperature to destructive levels. Although based on principles established by others in the past, my research group has spent the last 10 years developing REV into a practical drying technology. My goal is to develop an economical drying method to replace freeze drying for many applications. REV is currently protected by about a dozen patents, most of them owned by The University of British Columbia and these patents have been licensed to a Canadian company whose goal is to commercialize the technology. Today REV is used for drying a few high-value food products such as berries and mushrooms. We have shown that it is able to dry bacteria without killing the cells, as well as to dry several drugs, antibiotics, enzymes and antibodies with little or no damage. We hope to further prove the usefulness of the technology for drying and stabilizing vaccines, probiotic bacteria, and natural antimicrobial agents.

辐射能真空 (REV) 是一种在低温下快速干燥热敏材料的技术，以免损害生物活性。利用真空将水的沸点降低到略高于冰点甚至远低于冰点，然后利用微波快速蒸发水而不将温度升高到破坏性水平。尽管基于过去其他人建立的原理，我的研究小组在过去 10 年里一直将 REV 开发为实用的干燥技术。我的目标是开发一种经济的干燥方法来替代许多应用中的冷冻干燥。 REV 目前受到大约十二项专利的保护，其中大部分归不列颠哥伦比亚大学所有，这些专利已授权给一家加拿大公司，该公司的目标是将这项技术商业化。如今，REV 用于干燥一些高价值食品，例如浆果和蘑菇。我们已经证明，它能够干燥细菌而不杀死细胞，也能够干燥多种药物、抗生素、酶和抗体，而几乎不会造成任何损害。我们希望进一步证明该技术对于干燥和稳定疫苗、益生菌和天然抗菌剂的有用性。