Targeting myeloid cells to restrict gamma-herpesvirus spread

靶向骨髓细胞限制伽玛疱疹病毒传播

• 批准号: nhmrc : 1122070
• 负责人: A/Pr Philip Stevenson
• 金额: $ 43.89万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-myeloid-cells-herpesvirus-spread/946861
• 关键词: Targeting; myeloid; cells; restrict; gamma

Gamma-herpesviruses infect most people and cause cancers. Vaccines to date have worked poorly. We have identified a key role for myeloid cells in infection that suggests a new approach. Interferons restrict infection in some myeloid cells. We will test whether inducing interferons can make all myeloid cells restrictive and reduce chronic infection. We will test then whether myeloid-restricting antibodies can recruit the same defences to provide a basis for vaccination.

γ-疱疹病毒感染大多数人并导致癌症。迄今为止，疫苗效果不佳。我们已经确定了骨髓细胞在感染中的关键作用，这表明了一种新的方法。干扰素限制某些骨髓细胞的感染。我们将测试是否诱导干扰素可以使所有的骨髓细胞限制和减少慢性感染。然后我们将测试骨髓限制性抗体是否可以招募相同的防御，为疫苗接种提供基础。