Understanding how cytomegaloviruses establish systemic infection

了解巨细胞病毒如何建立全身感染

• 批准号: nhmrc : GNT1140169
• 负责人: A/Pr Philip Stevenson
• 金额: $ 66.81万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-cytomegaloviruses-establish-systemic-infection/1348285
• 关键词: Understanding; how; cytomegaloviruses; establish; systemic

Human cytomegalovirus (HCMV) infects most Australians, causes birth defects and harms transplant patients. Vaccines against it have worked poorly. HCMV spreads throughout the body and is never cleared. To control infection we must identify its key checkpoints. Using mouse CMV, we find that host dendritic cells, which normally defend against infections, are taken over and spread virus to new sites. The viral gene responsible is a potential target for intervention. We will define how it works.

人巨细胞病毒（HCMV）感染大多数澳大利亚人，导致出生缺陷和损害移植患者。针对它的疫苗效果不佳。HCMV在全身传播，从未被清除。为了控制感染，我们必须确定其关键检查点。使用小鼠CMV，我们发现通常防御感染的宿主树突状细胞被接管并将病毒传播到新的部位。病毒基因是一个潜在的干预目标。我们将定义它的工作原理。