Immune control of gamma-herpesvirus dissemination

γ-疱疹病毒传播的免疫控制

• 批准号: nhmrc : 1064015
• 负责人: A/Pr Philip Stevenson
• 金额: $ 35.15万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-control-gamma-herpesvirus-dissemination/455100
• 关键词: Immune; control; gamma; herpesvirus; dissemination

Human ?-herpesviruses persist for life, cause cancers and emerge with particular virulence when the immune system is weak. Vaccination against them is therefore an important health priority. We have shown for a related ?-herpesvirus of mice that live vaccines protect. Antibody seems to play a major role. We will test whether safer, recombinant vaccines are also sufficient to elicit protective antibody. Thus we can establish a viable strategy for preventing virus-induced human cancers.

人类？疱疹病毒终生存在，导致癌症，并在免疫系统薄弱时以特别的毒力出现。因此，接种疫苗是一项重要的卫生优先事项。我们已经展示了一个相关的？-活疫苗保护的小鼠疱疹病毒。抗体似乎起着重要作用。我们将测试更安全的重组疫苗是否也足以引发保护性抗体。因此，我们可以建立一个可行的战略，以防止病毒引起的人类癌症。