Skeletal muscle cell volume: a regulator of metabolism

骨骼肌细胞体积：新陈代谢的调节因子

• 批准号: 261427-2008
• 负责人: Roy, Brian
• 金额: $ 1.68万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=426599
• 关键词: Skeletal; muscle; cell; volume; regulator

The long term objective of the current proposal is to further investigate the role of changes in muscle cell fluid levels on the control of muscle metabolism, as we have previously shown that changes in muscle cell fluid levels lead to changes in how these cells metabolize energy. We will achieve a number of specific short term goals with this proposal; firstly, we will establish a detailed time course for changes in muscle cell fluid levels in response to changes in the composition of the fluid in which they are bathed. We will also determine the time course for recovery from such changes. Another goal of this work is to establish what intracellular signaling pathways are influenced by these changes in fluid volume and to determine the extent to which these pathways are altered. Finally, we will establish how the changes in these intracellular signaling pathways influence metabolism within skeletal muscle.

目前建议的长期目标是进一步研究肌细胞液水平变化对肌肉代谢控制的作用，因为我们以前已经证明，肌细胞液水平的变化会导致这些细胞如何代谢能量。 我们将实现一些具体的短期目标与此建议;首先，我们将建立一个详细的时间过程中的肌细胞液水平的变化，以响应其所沐浴的液体成分的变化。 我们还将确定从这些变化中恢复的时间进程。 这项工作的另一个目标是确定哪些细胞内信号通路受到这些液体体积变化的影响，并确定这些通路被改变的程度。 最后，我们将确定这些细胞内信号通路的变化如何影响骨骼肌内的代谢。