Skeletal muscle cell volume: a regulator of metabolism

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The long term objective of the current proposal is to further investigate the role of changes in muscle cell fluid levels on the control of muscle metabolism, as we have previously shown that changes in muscle cell fluid levels lead to changes in how these cells metabolize energy. We will achieve a number of specific short term goals with this proposal; firstly, we will establish a detailed time course for changes in muscle cell fluid levels in response to changes in the composition of the fluid in which they are bathed. We will also determine the time course for recovery from such changes. Another goal of this work is to establish what intracellular signaling pathways are influenced by these changes in fluid volume and to determine the extent to which these pathways are altered. Finally, we will establish how the changes in these intracellular signaling pathways influence metabolism within skeletal muscle.