The transcriptional control of the dendritic cell lineages

树突状细胞谱系的转录控制

• 批准号: nhmrc : 1048278
• 负责人: Prof Li Wu
• 金额: $ 44.67万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-control-dendritic-cell-lineages/112009
• 关键词: transcriptional; control; dendritic; cell; lineages

The immune system can discriminate between invading microorganisms and the body's own tissues. Dendritic cells are specialised to alert the immune system in the case of infection. In this project we aim to understand how dendritic cells are generated and how they function to control the immune response. We will achieve this aim by using state of the art genomic technologies to describe the genetic programme of dendritic cells. We hope that this knowledge will enable us to better harness the immune response in situations such as vaccination.

免疫系统可以区分入侵的微生物和人体自身的组织。树突状细胞专门负责在感染时向免疫系统发出警报。在这个项目中，我们的目标是了解树突状细胞是如何产生的以及它们如何发挥控制免疫反应的作用。我们将通过使用最先进的基因组技术来描述树突状细胞的遗传程序来实现这一目标。我们希望这些知识将使我们能够更好地利用疫苗接种等情况下的免疫反应。