Molecular genetic analysis of regulatory networks governing cytokinesis

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In order for a single cell to give rise to another, it must be able to replicate its genetic material, and then divide it equally into two independent daughter cells. The last crucial step of this process - where the mother cell is physically separated into two distinct entities - is called cytokinesis. Cytokinesis is achieved through the use of a ring-like structure that forms in the medial region of the cell. Upon receiving the proper signals, this ring constricts with such force that it is able to "cleave" the cell into two. Interestingly, research has shown that cells are able to monitor the constriction of the ring, and furthermore that mechanisms are in place to help maintain the physical integrity of this structure. This system is used to promote the successful completion of cytokinesis even when cells are subjected to stresses that might perturb their normal function. Broadly speaking, the research program concerns the genes and proteins required to ensure that the ring forms and constricts in a faithful and dependable manner. Of current interest is a specific protein that promotes the successful completion of cytokinesis by influencing a critical cellular regulator that is involved in determining which genes in a cell are turned on or off.