Development of a reliable, efficient and economic chiral drug separation process

点击翻译按钮获取中文摘要

Chirality is a major concern in the modern pharmaceutical, food and agricultural industries. The sale of chiral drugs is close to one-third of all drug sales worldwide. Ordinary chemical production methods for chiral drugs produce a racemic mixture containing enantiomers having identical chemical compositions but different structural orientations in space. It is quite common to find that one isomeric form has a therapeutic effect on the human body while its enantiomer is harmful or ineffective. Hence, there is obvious benefit from separating the two enantiomers to enhance drug's safety and tolerability. The importance of chirally pure drugs has risen dramatically in recent years due to new FDA regulations requiring that chiral drugs be as pure as possible containing a single pure enantiomer.