Synthesis and scale-up of enantiopure pharmaceuticals, TiO2 nanotubes and zeolitic nanomaterials

对映体纯药物、TiO2 纳米管和沸石纳米材料的合成和放大

• 批准号: 5748-2011
• 负责人: Rohani, Sohrab
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=544285
• 关键词: Synthesis; scale; up; enantiopure; pharmaceuticals

The objectives of the proposed research program are to synthesize and scale up the production of a series of industrially significant innovative nanomaterials ranging from the active pharmaceutical ingredients, enantiopure pharmaceuticals, photocatalysts, superhyrophobic particles/surfaces, and zeolitic like nanomaterials. A multi-scale engineering approach will be used to unravel the underlying phenomena at the atomic and molecular levels and to use process engineering and controls principles for efficient large scale production of the new nanomaterials. Direct crystallization and diasteremeric salts crystallization will be used for the enantioseparation of pharmaceutically significant conglomerates and racemic compounds, respectively. Magnetic iron oxide will be used as a hub along with organic linkers to synthesize zeolitic imidazolate frameworks (ZIFs) to load pharmaceuticals for controlled and targeted drug release. Using anodization, well-formed nano-tube arrays of TiO2 will be synthesized and Fe, C, N; organic dyes; and ZIF nanoparticles will be added to them to reduce their bandgap energy and improve their photosensitivity to visible light. These nanomaterials will be used for oxidation of pollutants, in solar cells, for hydrogen production, and to prepare superhydrophobic surfaces. The latter requires functionalization of the nano TiO2 by fluorine compounds. A major application of these functionalized nanmomaterials is for the effective separation of water oil (aqueous/organic) emulsions and mixtures which will have potential applications in oilsand processing, cleaning up of the tailings in the mining sites and oil spills. A series of metal organic framework (MOF) and ZIF nanomaterials will be synthesized using an assisted combined microwave and ultrasound approach. The proposed hybrid process in our lab has already resulted in yields as high as 100 times of the conventional solvothermal processes, and can revolutionize production of these materials and strongly affect the environmental protection (CO2 capture and cold temperature oxidation of CO), hydrogen storage and drug delivery systems.

拟议研究计划的目标是合成和扩大一系列具有工业意义的创新纳米材料的生产，包括活性药物成分、对映体药物、光催化剂、超疏水颗粒/表面和类沸石纳米材料。将使用多尺度工程方法来揭开原子和分子层面上的潜在现象，并使用过程工程和控制原理来有效地大规模生产新的纳米材料。直接结晶法和非对映盐结晶法将分别用于医药上重要的砾岩和外消旋化合物的对映体分离。磁性氧化铁将与有机连接物一起作为枢纽，合成沸石咪唑骨架(ZIF)，以负载药物，实现药物的控制和靶向释放。利用阳极氧化，将合成结构良好的二氧化钛纳米管阵列，并在其中添加Fe、C、N、有机染料和ZIF纳米颗粒，以降低其带隙能量，提高其对可见光的光敏性。这些纳米材料将用于污染物的氧化，用于太阳能电池，用于制氢，以及制备超疏水表面。后者需要用含氟化合物对纳米二氧化钛进行功能化处理。这些功能化纳米材料的一个主要应用是有效分离水、油(水/有机)乳液和混合物，这将在石油和石油加工、矿场尾矿清理和石油泄漏方面有潜在的应用。利用微波和超声辅助相结合的方法合成了一系列金属有机骨架(MOF)和ZIF纳米材料。我们实验室提出的混合工艺已经产生了高达传统溶剂热工艺100倍的产率，可以彻底改变这些材料的生产，并对环境保护(二氧化碳捕获和CO的冷温氧化)、氢气存储和药物输送系统产生重大影响。