A continuous microwave and ultrasonic reactor setup for the fast production of zeolites, metal organic frameworks (MOF) and pharmaceuticals

用于快速生产沸石、金属有机框架 (MOF) 和药物的连续微波和超声波反应器装置

• 批准号: 458494-2014
• 负责人: Rohani, Sohrab
• 金额: $ 10.92万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=541945
• 关键词: continuous; microwave; ultrasonic; reactor; setup

This proposal is to request a continuous microwave (MW) reactor setup and a flow through reactor with a high efficiency ultrasonic probe for the efficient conversion of coal fly ash to zeolites, synthesis of metal organic framework (MOF) nanoparticles and controlled nucleation and growth rates of pharmaceuticals. We have converted coal fly ash to zeolites, synthesized a number of industrially important metal organic frameworks (MOFs), and produced active pharmaceutical ingredients (APIs) in laboratory scale batch reactors (20 mL) using a combination of MW and UTS energy sources. In comparison with the conventional heating, UTS and MW increase the reaction rates by several orders of magnitude while the product quality in terms of cationic exchange capacities, the specific surface area, and particle size distribution are enhanced. The commercialization of our product series with applications in waste water treatment and adsorption of heavy metals, mercury in ppb range and hexavalent chromium; selective CO2 adsorption from industrial flue gas and biogas (from a mixture of methane and CO2 produced by anaerobic digestion of animal waste); as well as control of polymorphism in the pharmaceutical crystallization, requires the design of a large scale continuous reactor with controllable sources of MW and UTS energies. The requested pieces of equipment are chosen after careful consideration of the available suppliers, and are essential components of a 'bench scale' continuous process (400 mL reactor volume) that can help optimize the operating conditions for the design of a pilot-plant and industrial size zeolitization and MOFs and pharmaceuticals manufacturing plants. Access to the requested equipment in this proposal will lead to an efficient manufacturing process for the conversion of coal fly ash to a series of useful zeolites for the treatment of municipal and industrial wastewater streams, and synthesis of a series of MOF nanomaterials and pharmaceuticals. The requested equipment is indispensable for the commercialization of our products. The HQP will be trained in the fundamental and applied research and will have close interaction with our industrial partners.

该提议要求连续微波（MW）反应器设置和具有高效超声探头的流通式反应器，用于将粉煤灰有效转化为沸石、合成金属有机骨架（MOF）纳米颗粒以及药物的受控成核和生长速率。 我们已经将粉煤灰转化为沸石，合成了许多工业上重要的金属有机框架（MOF），并使用MW和UTS能源组合在实验室规模的间歇反应器（20 mL）中生产活性药物成分（API）。 与常规加热相比，UTS和MW将反应速率提高了几个数量级，同时在阳离子交换容量、比表面积和粒度分布方面的产品质量得到增强。我们的产品系列的商业化，应用于废水处理和吸附重金属，ppb范围内的汞和六价铬;从工业烟道气和沼气中选择性吸附CO2（来自动物粪便厌氧消化产生的甲烷和CO2的混合物）;以及控制药物结晶中的多晶型，需要设计具有MW和UTS能量可控来源的大型连续反应器。所要求的设备是在仔细考虑现有供应商后选择的，并且是“实验室规模”连续工艺（400 mL反应器体积）的基本组成部分，可以帮助优化中试工厂和工业规模沸石化和MOF以及制药工厂设计的操作条件。 获得本提案中所要求的设备将导致一种有效的制造工艺，将粉煤灰转化为一系列有用的沸石，用于处理城市和工业废水流，并合成一系列MOF纳米材料和药物。所要求的设备是我们产品商业化不可或缺的。HQP将接受基础和应用研究方面的培训，并将与我们的工业合作伙伴密切互动。