Synthesis and scale-up of enantiopure pharmaceuticals, TiO2 nanotubes and zeolitic nanomaterials

对映体纯药物、TiO2 纳米管和沸石纳米材料的合成和放大

• 批准号: 5748-2011
• 负责人: Rohani, Sohrab
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=568417
• 关键词: Synthesis; scale; up; enantiopure; pharmaceuticals

The objectives of the proposed research program are to synthesize and scale up the production of a series of industrially significant innovative nanomaterials ranging from the active pharmaceutical ingredients, enantiopure pharmaceuticals, photocatalysts, superhyrophobic particles/surfaces, and zeolitic like nanomaterials. A multi-scale engineering approach will be used to unravel the underlying phenomena at the atomic and molecular levels and to use process engineering and controls principles for efficient large scale production of the new nanomaterials. Direct crystallization and diasteremeric salts crystallization will be used for the enantioseparation of pharmaceutically significant conglomerates and racemic compounds, respectively. Magnetic iron oxide will be used as a hub along with organic linkers to synthesize zeolitic imidazolate frameworks (ZIFs) to load pharmaceuticals for controlled and targeted drug release. Using anodization, well-formed nano-tube arrays of TiO2 will be synthesized and Fe, C, N; organic dyes; and ZIF nanoparticles will be added to them to reduce their bandgap energy and improve their photosensitivity to visible light. These nanomaterials will be used for oxidation of pollutants, in solar cells, for hydrogen production, and to prepare superhydrophobic surfaces. The latter requires functionalization of the nano TiO2 by fluorine compounds. A major application of these functionalized nanmomaterials is for the effective separation of water oil (aqueous/organic) emulsions and mixtures which will have potential applications in oilsand processing, cleaning up of the tailings in the mining sites and oil spills. A series of metal organic framework (MOF) and ZIF nanomaterials will be synthesized using an assisted combined microwave and ultrasound approach. The proposed hybrid process in our lab has already resulted in yields as high as 100 times of the conventional solvothermal processes, and can revolutionize production of these materials and strongly affect the environmental protection (CO2 capture and cold temperature oxidation of CO), hydrogen storage and drug delivery systems.

拟议的研究计划的目标是合成和规模化生产一系列具有工业意义的创新纳米材料，包括活性药物成分，对映体纯药物，光催化剂，超疏水颗粒/表面和沸石类纳米材料。将采用多尺度工程方法来揭示原子和分子水平上的潜在现象，并使用工艺工程和控制原理来有效地大规模生产新的纳米材料。直接结晶和非对映体盐结晶将分别用于药学上重要的聚集体和外消旋化合物的对映体分离。磁性氧化铁将被用作中心沿着有机连接剂来合成沸石咪唑酯框架（ZIF），以装载用于受控和靶向药物释放的药物。使用阳极氧化，将合成良好形成的TiO 2纳米管阵列，并将Fe，C，N;有机染料;和ZIF纳米颗粒添加到其中以降低其带隙能量并提高其对可见光的光敏性。这些纳米材料将用于污染物的氧化、太阳能电池、制氢以及制备超疏水表面。后者需要通过氟化合物对纳米TiO 2进行功能化。这些功能化纳米材料的一个主要应用是有效分离水油（水/有机）乳液和混合物，这将在油砂加工，清理采矿场的尾矿和石油泄漏中具有潜在的应用。一系列金属有机骨架（MOF）和ZIF纳米材料将使用辅助组合微波和超声方法合成。我们实验室提出的混合工艺已经导致产量高达传统溶剂热工艺的100倍，并且可以彻底改变这些材料的生产，并强烈影响环境保护（CO2捕获和CO的低温氧化），储氢和药物输送系统。