Type I interferon signalling in bacterial infection

细菌感染中的 I 型干扰素信号传导

• 批准号: nhmrc : 1141504
• 金额: $ 49.92万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/type-i-interferon-bacterial-infection/1319479
• 关键词: Type; interferon; signalling; bacterial; infection

Infectious diseases are a leading cause of death in Australia. Activation of disease-fighting inflammasomes sets in motion rapid immune defenses against pathogens. In this project, we explore how cell-cell communication molecules known as type I interferons communicate with inflammasomes to achieve the best outcome in the body in response to deadly bacterial infection. Understanding how these signals communicate with one another could reveal new ways to fight infectious diseases.

在澳大利亚，传染病是主要的死亡原因。抗病炎症小体的激活启动了对病原体的快速免疫防御。在这个项目中，我们探索了被称为I型干扰素的细胞-细胞通讯分子如何与炎症体通讯，以在体内实现最佳结果，以应对致命的细菌感染。了解这些信号是如何相互通信的，可以揭示抗击传染病的新方法。