Tetramerization domains of TRPC channel

TRPC通道的四聚化结构域

• 批准号: 355726-2008
• 负责人: Boulay, Guylain
• 金额: $ 2.55万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=431730
• 关键词: Tetramerization; domains; TRPC; channel

Ion channels are transmembrane pores which allow the passage of ions into and out of a cell down the electrochemical gradient. There are hundreds of different ion channels that are regrouped inside protein family and they are distinguished based upon their ion selectivity, gating mechanism, and sequence similarity. One of these families is known as TRPC channels. These channels are very diverse in their physiological function and are activated following a hormonal stimulation, and this thought the animal kingdom.

离子通道是跨膜孔，它允许离子沿着电化学梯度进出细胞。蛋白质家族中有数百种不同的离子通道重组，并根据它们的离子选择性、门控机制和序列相似性来区分它们。其中一个家族被称为TRPC通道。这些通道在生理功能上非常多样化，在激素刺激下被激活，这被认为是动物王国。