Potential antimicrobial proteins for human health - value added products from the eggshell

对人类健康具有潜在作用的抗菌蛋白——来自蛋壳的增值产品

• 批准号: 365046-2008
• 负责人: Hincke, Maxwell
• 金额: $ 9.98万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=434438
• 关键词: Potential; antimicrobial; proteins; human; health

The objective of the project "Potential antimicrobial proteins for human health - Value added products from eggshell waste", which is targeted to the Quality Foods and Novel Bioproducts strategic grant program (Functional Foods and Neutraceuticals) is to build upon our recent research which has identified an antimicrobial protein associated with the egg. Working closely with an Ontario egg producer / breaker operation (Burnbrae Farms Ltd) and a major Canadian industrial concern in this sector, Inovatech Egg Products Inc, we will purify antimicrobial proteins from industrial eggshell breaker waste material and study their antimicrobial properties, mechanism of action and ability to protect mice against oral pathogen challenge. Potential for allergic elements in the purified material will be identified with a view to its elimination. Furthermore, in collaboration with Shaver Poultry Breeding Farms (ISA North America), single nucleotide polymorphisms (SNP's) will be identified that have potential for gene selection of breeding hens to produce eggs with enhanced antimicrobial protection.

该项目的目标是“潜在的抗菌蛋白对人类健康-蛋壳废物的增值产品”，这是针对优质食品和新型生物产品战略资助计划（功能食品和营养品）是建立在我们最近的研究，已经确定了与鸡蛋相关的抗菌蛋白。与安大略鸡蛋生产商/破碎机操作（Burnbrae农场有限公司）和加拿大在这一领域的主要工业关注，Inovatech蛋品公司密切合作，我们将从工业蛋壳破碎机废料中纯化抗菌蛋白，并研究其抗菌特性，作用机制和保护小鼠免受口腔病原体攻击的能力。将确定纯化材料中过敏元素的可能性，以消除过敏元素。此外，与Shaver家禽育种农场（伊萨北美）合作，将确定单核苷酸多态性（SNP），这些多态性具有对种蛋母鸡进行基因选择的潜力，以生产具有增强抗菌保护的鸡蛋。