Potential antimicrobial proteins for human health - value added products from the eggshell

对人类健康具有潜在作用的抗菌蛋白——来自蛋壳的增值产品

• 批准号: 365046-2008
• 负责人: Hincke, Maxwell
• 金额: $ 9.98万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=460887
• 关键词: Potential; antimicrobial; proteins; human; health

The objective of the project "Potential antimicrobial proteins for human health - Value added products from eggshell waste", which is targeted to the Quality Foods and Novel Bioproducts strategic grant program (Functional Foods and Neutraceuticals) is to build upon our recent research which has identified an antimicrobial protein associated with the egg. Working closely with an Ontario egg producer / breaker operation (Burnbrae Farms Ltd) and a major Canadian industrial concern in this sector, Inovatech Egg Products Inc, we will purify antimicrobial proteins from industrial eggshell breaker waste material and study their antimicrobial properties, mechanism of action and ability to protect mice against oral pathogen challenge. Potential for allergic elements in the purified material will be identified with a view to its elimination. Furthermore, in collaboration with Shaver Poultry Breeding Farms (ISA North America), single nucleotide polymorphisms (SNP's) will be identified that have potential for gene selection of breeding hens to produce eggs with enhanced antimicrobial protection.

“用于人类健康的潜在抗菌蛋白——来自蛋壳废料的增值产品”项目的目标是优质食品和新型生物制品战略资助计划（功能食品和中性食品），该项目的目标是建立在我们最近的研究基础上，该研究已经确定了一种与鸡蛋相关的抗菌蛋白。我们将与安大略省产蛋/破蛋企业（Burnbrae Farms Ltd）和该领域的加拿大主要工业企业innovatech egg Products Inc密切合作，从工业破蛋壳废料中纯化抗菌蛋白，并研究其抗菌特性、作用机制和保护小鼠免受口腔病原体攻击的能力。将鉴定纯化材料中潜在的过敏元素，以便消除其。此外，与Shaver Poultry Breeding Farms （ISA North America）合作，将鉴定具有基因选择潜力的单核苷酸多态性（SNP），以生产具有增强抗菌保护的鸡蛋。