Interactomics of oral fluids

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We hypothesize that the interactions among salivary proteins protect complex partners from proteolysis, modulate the biological activity of complexed proteins or serve as a delivery system for the distribution of secretory salivary proteins throughout the oral cavity. Since no detailed analyses of the salivary protein complexes present in whole saliva and salivary gland secretions have been carried out yet, these roles will be investigated in detail in the current proposal. State-of-the-art proteomics will be used, in combination with classical protein-protein interaction methods, to provide a greater understanding of the biological function of salivary protein complexes.